Chain Walking as a Strategy for Carbon–Carbon Bond Formation at Unreactive Sites in Organic Synthesis: Catalytic Cycloisomerization of Various 1, n-Dienes

T Hamasaki, Y Aoyama, J Kawasaki…

Index: Kochi, Takuya; Hamasaki, Taro; Aoyama, Yuka; Kawasaki, Junichi; Kakiuchi, Fumitoshi Journal of the American Chemical Society, 2012 , vol. 134, # 40 p. 16544 - 16547,4

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Citation Number: 2

Abstract

Carbon–carbon bond formation at unreactive sp3-carbons in small organic molecules via chain walking was achieved for the palladium-catalyzed cycloisomerization of 1, n-dienes. Various 1, n-dienes (n= 7–14) such as those containing cyclic alkenes, acyclic internal alkenes, and a trisubstituted alkene can be used for the chain-walking cycloisomerization/ hydrogenation process, and five-membered ring compounds including simple ...