Synthesis and psychoanaleptic properties of new compounds structurally related to diphenhydramine

…, A Champagnac, A Dehnel, G Lavielle…

Index: Buzas; Champagnac; Dehnel; Lavielle; Pommier Journal of Medicinal Chemistry, 1980 , vol. 23, # 2 p. 149 - 153

Full Text: HTML

Citation Number: 8

Abstract

In the attempt to prepare a new type of diphenhydramine derivatives, devoid of sedative side effects, we have synthesized a series of benzhydryloxyalkylpiperazines carrying a chain with a trivalent function (11). Surprisingly, some of the new compounds prepared, although structurally related to diphenhydramine, show novel, nonamphetaminic psychoanalpetic properties and lack pronounced peripheral anticholinergic activity. Chemistry. Most ...