Palladium-Catalyzed Cascade Process To Construct 1, 2, 5-Trisubstituted Pyrroles

YQ Zhang, DY Zhu, BS Li, YQ Tu, JX Liu…

Index: Zhang, Yong-Qiang; Zhu, Dao-Yong; Li, Bao-Sheng; Tu, Yong-Qiang; Liu, Ji-Xin; Lu, Yong; Wang, Shao-Hua Journal of Organic Chemistry, 2012 , vol. 77, # 8 p. 4167 - 4170

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Citation Number: 27

Abstract

A novel palladium-catalyzed cascade allylic amination/intramolecular hydroamination/ isomerization process of protected enynol 1 and primary amine 2 has been explored, which constructs the important 1, 2, 5-trisubstituted pyrroles. This transformation offers an alternative synthetic methodology capable of generating substituted pyrroles in a straightforward way.