The Journal of Organic Chemistry

A novel synthesis of homopiperazine and its monomethyl derivatives

F Poppelsdorf, RC Myerly

Index: Poppelsdorf,F.; Myerly,R.C. Journal of Organic Chemistry, 1961 , vol. 26, p. 131 - 134

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Citation Number: 9

Abstract

Homopiperazine has been synthesized in a yield of about 32% by a new method involving the catalytic reductive cyclization of N-(2-~ yanoethyl) ethylenediamine. 1-, 2-, 5-, and &methylhomopiperazine, the four possible monomethylhomopiperazines, were prepared analogously. N-(2'-Aminoethyl)-1, 3-propanediamine and its monomethyl derivatives were formed as co-products in 28 to 50% yields.