Potent histone deacetylase inhibitors: N-hydroxybenzamides with antitumor activities

…, Y Nagaoka, H Kuwajima, C Seno, S Maruyama…

Index: Maeda, Taishi; Nagaoka, Yasuo; Kuwajima, Hiroshi; Seno, Chieko; Maruyama, Sakiko; Kurotaki, Mineko; Uesato, Shinichi Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 16 p. 4351 - 4360

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Citation Number: 19

Abstract

The screening tests of N-hydroxybenzamides for their HDAC-inhibitory activities led to the discovery of the promising compounds with a 2-naphthylcarbonyl group and with a 1, 4- biphenylcarbonyl group. These compounds were further modified to optimize their physico- chemical profile. As a result, the inhibitor with a 6-amino-2-naphthylcarbonyl was obtained, which showed not only promising growth inhibitions against a panel of tumor cells, but ...