Modulable and Highly Diastereoselective Carbometalations of Cyclopropenes

D Didier, PO Delaye, M Simaan, B Island…

Index: Didier, Dorian; Delaye, Pierre-Olivier; Simaan, Marwan; Island, Biana; Eppe, Guillaume; Eijsberg, Hendrik; Kleiner, Amir; Knochel, Paul; Marek, Ilan Chemistry - A European Journal, 2014 , vol. 20, # 4 p. 1038 - 1048

Full Text: HTML

Citation Number: 20

Abstract

Abstract The copper-catalyzed carbomagnesiation reaction of cyclopropenyl esters 1 leads to various substituted cyclopropanes species 3 in good yields with very high diastereoselectivities. The reaction proceeds through a syn-chelated carbomagnesiation reaction and could be extended to various cyclopropenylmethyl ester derivatives 5. The potential of this approach was illustrated by the preparation of two consecutive all-carbon ...