Tetrahedron letters

The synthesis of branched steroidal prodrugs of nitrogen mustard for antitumor targeting via reconstituted LDL

GM Dubowchik, RA Firestone

Index: Dubowchik, Gene M.; Firestone, Raymond A. Tetrahedron Letters, 1994 ,  vol. 35,  # 26  p. 4523 - 4526

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Citation Number: 6

Abstract

Abstract Bis and tris nitrogen mustard oleoyl-steroid carbamates were synthesized from commercially available cholenic acids for antitumor drug targeting via the LDL pathway. The tris-mustards were prepared through triester intermediates made from selective alkylation of the dianion of t-butyl 3-(diethyl malonyl)-propionate 10 with steroid iodides 8.