Synthesis of pyrimidoblamic acid and epipyrimidoblamic acid

Y Aoyagi, MS Chorghade, AA Padmapriya…

Index: Aoyagi, Yoshiaki; Chorghade, Mukund S.; Padmapriya, Abeysinghe A.; Suguna, Hosbett; Hecht, Sidney M. Journal of Organic Chemistry, 1990 , vol. 55, # 26 p. 6291 - 6298

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Citation Number: 24

Abstract

The N-protected pyrimidine moieties of bleomycin (pyrimidoblamic acid, 1) and epibleomycin are reported. In addition to a complete description of a synthetic route outlined earlier (Arai, H.; Hagmann, WK; Suguna, H.; Hecht, SM J. Am. Chem. SOC 1980, 102, 6631), a new route is also presented that provides access to multigram quantities of pyrimidoblamic acid. Because bleomycin and epibleomycin, which differ only in the orientation of the ...

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