A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitor Atazanavir

L Dalla-Vechia, B Reichart, T Glasnov…

Index: Organic and Biomolecular Chemistry, , vol. 11, # 39 p. 6806 - 6813

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Citation Number: 19

Abstract

... ranked continuous flow processing as a high priority research area for pharmaceutical and fine chemical manufacturing. ... 1,2 A particularly challenging area in flow chemistry is to perform multi-step reaction sequences ... 5, and Pd(PPh 3 ) 4 as a catalyst in 2.3 mL of organic solvent ...

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