Synthetic nonpsychotropic cannabinoids with potent antiinflammatory, analgesic, and leukocyte antiadhesion activities

…, A Breuer, WA Devane, S Colodner…

Index: Burstein, Sumner H.; Audette, Charlene A.; Breuer, Aviva; Devane, William A.; Colodner, Sharona; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 17 p. 3135 - 3141

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Citation Number: 88

Abstract

Two strategies for the design of therapeutically useful cannabinoids have been combined to produce compounds with greatly increased antiinflammatory activity and with a low potential for adverse side effects. Enantiomeric cannabinoids with a carboxylic acid group at position 7 and with an elongated and branched alkyl sidechain at position 5'have been synthesized and tested for antiinflammatory activity. They were effective when given orally at doses of ...