Macromolecular Bioscience 2016-01-01

Chemoenzymatic Synthesis of Oligo(L-cysteine) for Use as a Thermostable Bio-Based Material.

Yinan Ma, Ryota Sato, Zhibo Li, Keiji Numata

Index: Macromol. Biosci. 16 , 151-9, (2016)

Full Text: HTML

Abstract

Oligomerization of thiol-unprotected L-cysteine ethyl ester (Cys-OEt) catalyzed by proteinase K in aqueous solution has been used to synthesize oligo(L-cysteine) (OligoCys) with a well-defined chemical structure and relatively large degree of polymerization (DP) up to 16-17 (average 8.8). By using a high concentration of Cys-OEt, 78.0% free thiol content was achieved. The thermal properties of OligoCys are stable, with no glass transition until 200 °C, and the decomposition temperature could be increased by oxidation. Chemoenzymatically synthesized OligoCys has great potential for use as a thermostable bio-based material with resistance to oxidation.© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Related Compounds

  • H-Cys-OEt.HCl
  • L-Cysteine methyl...

Related Articles:

GC-MS analysis of S-nitrosothiols after conversion to S-nitroso-N-acetyl cysteine ethyl ester and in-injector nitrosation of ethyl acetate.

2009-10-15

[J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(28) , 3442-55, (2009)]

Effect of cysteine ethylester hydrochloride (Cystanin) on host defense mechanisms (V): Potentiation of nitroblue tetrazolium reduction and chemiluminescence in macrophages or leukocytes of mice or rats.

1990-05-01

[Jpn. J. Pharmacol. 53(1) , 57-66, (1990)]

Oral L-cysteine ethyl ester (LCEE) reduces amoebic gill disease (AGD) in Atlantic salmon Salmo salar.

2005-08-09

[Dis. Aquat. Organ. 66(1) , 21-8, (2005)]

Radioprotectant and radiosensitizer effects on sterility of gamma-irradiated bone.

2008-08-01

[Clin. Orthop. Relat. Res. 466(8) , 1796-803, (2008)]

Usage of radiopharmaceuticals in the development of pharmaceutical drug delivery systems: validation of [99mTc]DTPA and [99mTc]ECD.

2004-03-01

[Eur. J. Pharm. Biopharm. 57(2) , 347-52, (2004)]

More Articles...