Beta-galactosidase catalyzed selective galactosylation of aromatic compounds.
Nicolas Bridiau, Selma Taboubi, Nejib Marzouki, Marie Dominique Legoy, Thierry Maugard
Index: Biotechnol. Prog. 22(1) , 326-30, (2006)
Full Text: HTML
Abstract
A new approach to galacto-oligosaccharides and galacto-conjugates synthesis performed by the beta-galactosidase from Kluyveromyces lactis is reported. The enzymatic galactosylation of eight kinds of adsorbed aromatic primary alcohols, in particular the two drugs guaifenesin and chlorphenesin, gave the corresponding beta-D-galacto-pyranosides in yields ranging between approximately 10% and 96%. For the first time, we have showed that the adsorption of acceptor substrates onto solid supports such as silica gel influences the yield and the selectivity of galacto-conjugates synthesis. In particular, we observed that adsorption of acceptor favored the synthesis of digalactosylated compounds.
Related Compounds
Related Articles:
2003-09-01
[Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 59(11) , 2511-7, (2003)]
Synthesis and characterization of new 2-(alkylamino) acetamides. Mancilla T, et al.
[ARKIVOC 11 , 37-47, (2003)]
Synthesis and fungicidal activity of N-[4-(4-fluoro) phenyl-2-piperidin-4-yl-thiazol-5-yl] pyrimidin-2-yl-N-phenylamines on Phytophthora capsici. Choi W-S, et al.
[J. Korean Soc. Appli. Biol. Chem. 53(2) , 206-14, (2010)]