Acta biologica et medica Germanica 1981-01-01

Incorporation of chemically modified proteins into liposomes.

R Koelsch, J Lasch, A L Klibanov, V P Torchilin

Index: Acta Biol. Med. Ger. 40(3) , 331-5, (1981)

Full Text: HTML

Abstract

Enzymes, not anchored into bilayers of membranes like trypsin, alpha-chymotrypsin, and carboxypeptidase A are chemically modified by acylation with fatty acids chlorides. This treatment renders these proteins hydrophobic so that they can combine with the phospholipid membrane of liposomes. This report deals with the incorporation of modified enzymes into liposomes prepared by different methods.

Related Compounds

  • Palmitoyl chloride
  • Stearoyl chloride

Related Articles:

Establishment of LC-MS methods for the analysis of palmitoylated surfactant proteins.

2015-07-01

[J. Lipid Res. 56 , 1370-9, (2015)]

Lipophilic prodrugs of apomorphine I: preparation, characterisation, and in vitro enzymatic hydrolysis in biorelevant media.

2015-01-01

[Eur. J. Pharm. Biopharm. 89 , 216-23, (2015)]

Use of multivariate statistical techniques to optimize the separation of 17 capsinoids by ultra performance liquid chromatography using different columns.

2015-03-01

[Talanta 134 , 256-63, (2015)]

Polymer micelle formulations of proteasome inhibitor carfilzomib for improved metabolic stability and anticancer efficacy in human multiple myeloma and lung cancer cell lines.

2015-11-01

[J. Pharmacol. Exp. Ther. 355 , 168-73, (2015)]

Assessment of acylation routes and structural characterisation by liquid chromatography/tandem mass spectrometry of semi-synthetic acyl ester analogues of lipophilic marine toxins.

2014-12-15

[Rapid Commun. Mass Spectrom. 28(23) , 2605-16, (2014)]

More Articles...