A direct approach to the synthesis of famciclovir and penciclovir

…, M Dales, GP Johnson, S O'Donnell…

Index: Choudary, Bernadette M.; Geen, Graham R.; Kincey, Peter M.; Parratt, Martin J.; Dales, J. Robert M.; Johnson, Graham P.; O'Donnell, Steven; Tudor, David W.; Woods, Neil Nucleosides and Nucleotides, 1996 , vol. 15, # 5 p. 981 - 994

Full Text: HTML

Citation Number: 18

Abstract

Abstract Reaction of 2-amino-6-chloropurine with triethyl 3-bromopropane-1, 1, 1- tricarboxylate followed by decarbethoxylation/transesterification of the unpurified product was the key sequence in synthesising both the anti-herpesvirus agent penciclovir and its oral from famciclovir in three isolated steps.

Related Articles:

Practical syntheses of penciclovir and famciclovir from N2-acetyl-7-benzylguanine

[Torii, Takayoshi; Shiragami, Hiroshi; Yamashita, Keizo; Suzuki, Yumiko; Hijiya, Toyoto; Kashiwagi, Tatsuki; Izawa, Kunisuke Tetrahedron, 2006 , vol. 62, # 24 p. 5709 - 5716]

Novel radiosynthesis of PET HSV-tk gene reporter probes [18 F] FHPG and [18 F] FHBG employing dual Sep-Pak SPE techniques

[Wang, Ji-Quan; Zheng, Qi-Huang; Fei, Xiangshu; Mock, Bruce H.; Hutchins, Gary D. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3933 - 3938]

Novel radiosynthesis of PET HSV-tk gene reporter probes [18 F] FHPG and [18 F] FHBG employing dual Sep-Pak SPE techniques

[Wang, Ji-Quan; Zheng, Qi-Huang; Fei, Xiangshu; Mock, Bruce H.; Hutchins, Gary D. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3933 - 3938]

Novel radiosynthesis of PET HSV-tk gene reporter probes [18 F] FHPG and [18 F] FHBG employing dual Sep-Pak SPE techniques

[Wang, Ji-Quan; Zheng, Qi-Huang; Fei, Xiangshu; Mock, Bruce H.; Hutchins, Gary D. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3933 - 3938]

Novel radiosynthesis of PET HSV-tk gene reporter probes [18 F] FHPG and [18 F] FHBG employing dual Sep-Pak SPE techniques

[Wang, Ji-Quan; Zheng, Qi-Huang; Fei, Xiangshu; Mock, Bruce H.; Hutchins, Gary D. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3933 - 3938]

More Articles...