Macromolecular Bioscience 2015-11-01

A New Hyaluronic Acid Derivative Obtained from Atom Transfer Radical Polymerization as a siRNA Vector for CD44 Receptor Tumor Targeting.

Fabio Salvatore Palumbo, Antonella Bavuso Volpe, Flavia Bongiovì, Giovanna Pitarresi, Gaetano Giammona

Index: Macromol. Biosci. 15 , 1605-15, (2015)

Full Text: HTML

Abstract

Two derivatives of hyaluronic acid (HA) have been synthesized by atom transfer radical polymerization (ATRP), starting from an ethylenediamino HA derivative (HA-EDA) and by using diethylaminoethyl methacrylate (DEAEMA) as a monomer for polymerization. Both samples, indicated as HA-EDA-pDEAEMA a and b, are able to condense siRNA, as determined by gel retardation assay and resulting complexes show a size and a zeta potential value dependent on polymerization number, as determined by dynamic light scattering measurements. In vitro studies performed on HCT 116 cell line, that over express CD44 receptor, demonstrate a receptor mediated uptake of complexes, regardless of their surface charge. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Related Compounds

  • 1-(3-Dimethylamino...
  • Heavy water
  • Acetone
  • 1,2-Ethanediamine
  • dichloroethane
  • Tetrabutylammonium...
  • Dimethyl sulfoxide
  • L-Glutamine
  • Bis(4-nitrophenyl)...
  • Diethylamine

Related Articles:

Minimizing the non-specific binding of nanoparticles to the brain enables active targeting of Fn14-positive glioblastoma cells.

2015-02-01

[Biomaterials 42 , 42-51, (2014)]

Altering in vivo macrophage responses with modified polymer properties.

2015-07-01

[Biomaterials 56 , 187-97, (2015)]

Species-dependent binding of new synthesized bicalutamide analogues to albumin by optical biosensor analysis.

2015-01-01

[J. Pharm. Biomed. Anal. 111 , 324-32, (2015)]

Herceptin conjugated PLGA-PHis-PEG pH sensitive nanoparticles for targeted and controlled drug delivery.

2015-06-20

[Int. J. Pharm. 487 , 81-90, (2015)]

Development of poly (I:C) modified doxorubicin loaded magnetic dendrimer nanoparticles for targeted combination therapy.

2014-10-01

[Biomed. Pharmacother. 68(8) , 979-87, (2014)]

More Articles...