International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology 1991-01-01

Development of radiolabelled albumin microspheres: a comparison of gamma-emitting radioisotopes of iodine (131I) and indium (111In/113mIn).

N Willmott, T Murray, R Carlton, Y Chen, H Logan, G McCurrach, R G Bessent, J A Goldberg, J Anderson, J H McKillop

Index: Int. J. Rad. Appl. Instrum. B 18(7) , 687-94, (1991)

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Abstract

Biodegradable albumin microspheres have been prepared incorporating either 131I or 111In/111In. Using cDTPAA/albumin molar ratios of 1, 3 and 10, approx. 0.7, 2.1 and 7 molecules of DTPA could be coupled to an albumin molecule, labelling efficiency being constant over this range. Because 131I microspheres were more stable in plasma than the system labelled with radionuclides of indium it was selected for clinical evaluation: potential uses of this radiopharmaceutical are illustrated.

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