Carbohydrate polymers 2015-10-05

Stoichiometric C6-oxidation of hyaluronic acid by oxoammonium salt TEMPO⁺Cl⁻ in an aqueous alkaline medium.

Irina Yu Ponedel'kina, Elvira A Khaibrakhmanova, Tatyana V Tyumkina, Irina V Romadova, Victor N Odinokov

Index: Carbohydr. Polym. 130 , 69-76, (2015)

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Abstract

This paper reports the selective oxidation of hyaluronic acid (HA) by stoichiometric quantity of 2,2,6,6-tetramethylpiperidine-1-oxoammonium chloride (TEMPO(+)) in aqueous alkaline medium. High efficiency of the HA oxidation and quantitative yield of carboxy-HA per starting TEMPO(+), as well as unusual behavior of the oxidation system generating an oxygen upon alkali-induced oxoammonium chloride decomposition are demonstrated. The scheme for HA oxidation involving both TEMPO(+) and oxygen produced upon the TEMPO(+)Cl(-) decomposition and/or air oxygen is proposed. For comparison, the data on stoichiometric oxidation of such substrates as dermatan sulfate, water-soluble potato starch, methyl 2-acetamido-2-deoxy-β-d-glucopyranoside and ethanol are presented. Copyright © 2015 Elsevier Ltd. All rights reserved.

Related Compounds

  • Sodium dithionite
  • 2,2,6,6-Tetramethy...

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