Selective deprotection of isopropyl esters, carbamates and carbonates with aluminum chloride

GL Chee

Index: Chee Synlett, 2001 , # 10 p. 1593 - 1595

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Citation Number: 2

Abstract

Abstract: The O-isopropyl bond of isopropyl esters, carbamates, and carbonates has been effectively and selectively cleaved by treatment with AlCl3 in nitromethane at 0–50 C to give carboxylic acids, amines, and alcohols, respectively, in good to excellent yields. Key words: isopropoxycarbonyls, selective deprotection, aluminum chloride, nitromethane, carbocations