Bioorganic & Medicinal Chemistry Letters 2009-04-01

Semi-synthetic analogs of pinitol as potential inhibitors of TNF-alpha cytokine expression in human neutrophils.

Khurshid A Bhat, Bhahwal A Shah, Kuldeep K Gupta, Anjali Pandey, Sarang Bani, Subhash C Taneja, Khurshid A. Bhat, Bhahwal A. Shah, Kuldeep K. Gupta, Anjali Pandey, Sarang Bani, Subhash C. Taneja

Index: Bioorg. Med. Chem. Lett. 19 , 1939-43, (2009)

Full Text: HTML

Abstract

Semi-synthetic analogs of pinitol were subjected to screening by determining TNF-alpha expression in human neutrophils using flowcytometry. Among the tested compounds, three derivatives displayed more than 50% inhibition of TNF-alpha cytokine secretion in LPS induced stimulated neutrophils and can be considered as potent anti-inflammatory moieties.

Related Compounds

  • D-Pinitol

Related Articles:

Attenuation of oxidative stress and alteration of hepatic tissue ultrastructure by D-pinitol in streptozotocin-induced diabetic rats.

2010-06-01

[Free Radic. Res. 44(6) , 668-78, (2010)]

The immunosuppressive effects of Agyrolobium roseum and pinitol in experimental animals.

2011-02-01

[Int. Immunopharmacol. 11(2) , 286-91, (2011)]

Determination of D-pinitol in carob syrup.

2011-09-01

[Int. J. Food Sci. Nutr. 62(6) , 572-6, (2011)]

Pancreatic tissue protective nature of D-Pinitol studied in streptozotocin-mediated oxidative stress in experimental diabetic rats.

2009-11-10

[Eur. J. Pharmacol. 622(1-3) , 65-70, (2009)]

A single acute dose of pinitol from a naturally-occurring food ingredient decreases hyperglycaemia and circulating insulin levels in healthy subjects.

2013-06-01

[Food Chem. 141(2) , 1267-72, (2013)]

More Articles...