An improved method for Lewis acid catalyzed phosphoryl transfer with Ti (t-BuO) 4
S Jones, D Selitsianos, KJ Thompson…
Index: Jones, Simon; Selitsianos, Dimitrios; Thompson, Kate J.; Toms, Steven M. Journal of Organic Chemistry, 2003 , vol. 68, # 13 p. 5211 - 5216
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Citation Number: 53
Abstract
Several inorganic esters have been evaluated as phosphoryl transfer catalysts. Of these, Ti (t-BuO) 4 was found to be the most effective catalyst giving excellent yields of the desired phosphate esters. The loading of the catalyst could be reduced to a little as 5 mol% for a majority of substrates with no loss in the yield of product. This methodology is significantly more versatile than using TiCl4 and is suitable for the phosphorylation of more complex ...
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