Novel isoprenoyl nanoassembled prodrug for paclitaxel delivery

…, J Mougin, C Gueutin, D Brambilla, J Caron…

Index: Mura, Simona; Zouhiri, Fatima; Lerondel, Stephanie; Maksimenko, Andrei; Mougin, Julie; Gueutin, Claire; Brambilla, Davide; Caron, Joachim; Sliwinski, Eric; Lepape, Alain; Desmaele, Didier; Couvreur, Patrick Bioconjugate Chemistry, 2013 , vol. 24, # 11 p. 1840 - 1849

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Citation Number: 17

Abstract

A new paclitaxel (Ptx) prodrug was designed by coupling a single terpene unit (MIP) to the hydroxyl group in position 2′ of the drug molecule. Using a squalene derivative of polyethylene glycol (SQ-PEG) as surface active agent, the resulting bioconjugate (PtxMIP) self-assembled in water leading to the formation of stable nanoparticles (PtxMIP_SQ-PEG NPs) with an impressively high drug loading (82%). In vivo, the anticancer activity of this ...

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