Synthesis and evaluation of a 125 I-labeled iminodihydroquinoline-derived tracer for imaging of voltage-gated sodium channels

C Pérez-Medina, N Patel, M Robson…

Index: Perez-Medina, Carlos; Patel, Niral; Robson, Mathew; Lythgoe, Mark F.; Arstad, Erik Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 18 p. 5170 - 5173

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Abstract

Abstract In vivo imaging of voltage-gated sodium channels (VGSCs) can potentially provide insights into the activation of neuronal pathways and aid the diagnosis of a number of neurological diseases. The iminodihydroquinoline WIN17317-3 is one of the most potent sodium channel blockers reported to date and binds with high affinity to VGSCs throughout the rat brain. We have synthesized a 125 I-labeled analogue of WIN17317-3 and ...

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