Heterocyclic basic compounds. XII. 7-Bromo-and 7-iodo-quinolines

AE Conroy, HS Mosher…

Index: Conroy et al. Journal of the American Chemical Society, 1949 , vol. 71, p. 3236

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Abstract

3-Carbethoxy-4-hydroxy-7-bromoquinoline.-The intermediate ethyl a-carbethoxy-0-rn- bromoanilinoacrylate was obtained in 40% yield (45 9.) by allowing a mixture of 50 g. of m- bromoanilinel* and 63 g. of ethoxymethylenemalonic ester” to stand overnight. The resulting solid mass was twice recrystallized from a 1: 1 osolution of ether and ligroin; white needles, mp 70-71. This material, 40 g., was cyclized by refluxing in diphenyl ether according to ...

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