Direct Synthesis of a Trifluoromethyl Copper Reagent from Trifluoromethyl Ketones: Application to Trifluoromethylation

H Serizawa, K Aikawa, K Mikami

Index: Serizawa, Hiroki; Aikawa, Kohsuke; Mikami, Koichi Chemistry - A European Journal, 2013 , vol. 19, # 52 p. 17692 - 17697

Full Text: HTML

Citation Number: 33

Abstract

Trifluoromethyl compounds have attracted much attention in the pharmaceutical and agrochemical industries due to the unique properties of the trifluoromethyl group.[1, 2] Various synthetic methods for such compounds have so far been developed by the use of trifluoromethyl organometallic (MCF3) reagents.[3] However, hard lithium and magnesium cations cannot be employed for such reagents, because these MCF3 reagents are ...

Related Articles:

Ruthenium (II)–NNN complex catalyzed Oppenauer-type oxidation of secondary alcohols

[Wang, Qingfu; Du, Wangming; Liu, Tingting; Chai, Huining; Yu, Zhengkun Tetrahedron Letters, 2014 , vol. 55, # 9 p. 1585 - 1588]

Catalytic Aerobic Oxidative Cleavage of Oximes, Tosylhydrazones and N, N-Dimethylhydrazones to Carbonyl Compounds

[Blay, Gonzalo; Benach, Elisabeth; Fernandez, Isabel; Galletero, Sales; Pedro, Jose R.; Ruiz, Rafael Synthesis, 2000 , # 3 p. 403 - 406]

Wacker oxidation of alkenes using a fluorous biphasic system. A mild preparation of polyfunctional ketones

[Betzemeier, Bodo; Lhermitte, Frederic; Knochel, Paul Tetrahedron Letters, 1998 , vol. 39, # 37 p. 6667 - 6670]

Iodine-catalyzed disproportionation of aryl-substituted ethers under solvent-free reaction conditions

[Organic and Biomolecular Chemistry, , vol. 11, # 12 p. 1978 - 1999]

Palladium-catalyzed enantioselective oxidations of alcohols using molecular oxygen

[Journal of the American Chemical Society, , vol. 123, # 30 p. 7475 - 7476]

More Articles...