Cyclic guanidines as dual 5-HT 5A/5-HT 7 receptor ligands: Structure–activity relationship elucidation

…, A Alanine, S Kolczewski, F Blasco, L Steward

Index: Peters, Jens-Uwe; Luebbers, Thomas; Alanine, Alexander; Kolczewski, Sabine; Blasco, Francesca; Steward, Lucinda Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 1 p. 256 - 261

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Citation Number: 11

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The optimisation of affinity and selectivity in a novel series of dual 5-HT 5A /5-HT 7 receptor ligands is described. Brain penetrant 2-aminodihydroquinazolines with low nanomolar affinities were identified. ... The optimisation of affinity and selectivity in a novel series of dual 5-HT 5A ...

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