European Journal of Medicinal Chemistry 2012-08-01

Anthranilic acid-based diamides derivatives incorporating aryl-isoxazoline pharmacophore as potential anticancer agents: design, synthesis and biological evaluation.

Liqiao Shi, Rui Hu, Yanhong Wei, Ying Liang, Ziwen Yang, Shaoyong Ke

Index: Eur. J. Med. Chem. 54 , 549-56, (2012)

Full Text: HTML

Abstract

A series of novel anthranilic diamides derivatives containing aryl-isoxazoline moiety were designed and synthesized as a part of our ongoing search for potential anticancer agents. Their structures were confirmed by (1)H NMR, (13)C NMR and ESI-MS analyses. The preliminary assays showed that some of the compounds displayed moderate to good antitumor activities against human lung cancer (NCI-H460), hepatocellular liver carcinoma (HepG2), gastric cancer (SGC-7901 and BGC-823) and breast epithelial adenocarcinoma (MCF-7) cell lines at μM level, which might be developed as novel lead scaffold for potential anticancer agents.Copyright © 2012 Elsevier Masson SAS. All rights reserved.

Related Compounds

  • Anthranilic acid
  • N,N,N',N'-Tetram...

Related Articles:

Toxicological assessment and management options for boat pressure-washing wastewater.

2015-04-01

[Ecotoxicol. Environ. Saf. 114 , 164-70, (2015)]

Development of a quantitative mass spectrometry multi-attribute method for characterization, quality control testing and disposition of biologics.

2015-01-01

[MAbs 7 , 881-90, (2015)]

Coformer screening using thermal analysis based on binary phase diagrams.

2014-08-01

[Pharm. Res. 31(8) , 1946-57, (2014)]

Stable isotopic labeling-based quantitative targeted glycomics (i-QTaG).

2015-01-01

[Biotechnol. Prog. 31 , 840-8, (2015)]

Comparative studies of N-glycans and glycosaminoglycans present in SIRC (Statens Seruminstitut rabbit cornea) cells and corneal epithelial cells from rabbit eyes.

2014-07-01

[Curr. Eye Res. 39(7) , 686-94, (2014)]

More Articles...