Carbohydrate Research 2015-03-20

Synthesis and evaluation of glyco-coated liposomes as drug carriers for active targeting in drug delivery systems.

Akiharu Ueki, Keita Un, Yuka Mino, Mitsuru Yoshida, Shigeru Kawakami, Hiromune Ando, Hideharu Ishida, Fumiyoshi Yamashita, Mitsuru Hashida, Makoto Kiso

Index: Carbohydr. Res. 405 , 78-86, (2015)

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Abstract

Novel sugar-conjugated cholesterols, β-Gal-, α-Man-, β-Man-, α-Fuc-, and β-Man-6P-S-β-Ala-Chol, were synthesized and incorporated into liposomes. In vitro experiments using the glyco-coated liposomes showed that the glyco-coated liposomes are efficiently taken up by cells expressing carbohydrate-binding receptors selectively. Glyco-coated liposomes are promising candidates for drug delivery vehicles. Copyright © 2014 Elsevier Ltd. All rights reserved.

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