Synthesis of N-Boc-β-Aryl Alanines and of N-Boc-β-Methyl-β-aryl Alanines by Regioselective Ring-Opening of Enantiomerically Pure N-Boc-Aziridines

E Medina, A Moyano, MA Pericàs…

Index: Medina; Moyano; Pericas; Riera Journal of Organic Chemistry, 1998 , vol. 63, # 23 p. 8574 - 8578

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Citation Number: 30

Abstract

The stereoselective synthesis of unnatural R-amino acids1 is currently a subject of enormous interest mainly due to the increasing biological and therapeutic applications of modified peptides. 2 Over the last few years, we have been involved in a project devoted to the enantioselective synthesis of several structural types of N-Boc amino acids and dipeptide isosteres. 3, 4 Our approach, which is based on the intermediacy of ...