Molecules 2009-01-01

Azolyacetones as precursors to indoles and naphthofurans facilitated by microwave irradiation with simultaneous cooling.

Saleh Mohammed Al-Mousawi, Morsy Ahmed El-Apasery

Index: Molecules 14(8) , 2976-84, (2009)

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Abstract

Phthalimide reacted with phenacyl bromide under microwave irradiation to yield phenacyl isoindolidene-1,3-dione (3b), while 3a reacted with phenylhydrazine to yield the phenylhydrazone 4 that was readily converted into indoylphthalimide 8. Similarly N-benzotriazolylacetone (6a) reacted with phenyl hydrazine to yield the phenylhydrazone 7a that was converted into indoylbenzotriazole 9. Treatment of 8 with hydrazine hydrate afforded a mixture of phthalhydrazide 10 and 3-amino-2-methylindole (11). Reacting enaminone 13 with naphthoquinone (14) afforded the aryl naphthofuran 17. The possibility of the formation of the aldehyde 18 was excluded based on HMQC, which revealed that the carbonyl carbon is not linked to any hydrogen.

Related Compounds

  • 2-Bromoacetophenon...
  • O-Phthalimide
  • Potassium phthalim...

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