The contribution of the N-terminal structure of polymyxin B peptides to antimicrobial and lipopolysaccharide binding activity

N Sakura, T Itoh, Y Uchida, K Ohki, K Okimura…

Index: Sakura, Naoki; Itoh, Tatsuya; Uchida, Yoshiki; Ohki, Kazuhiro; Okimura, Keiko; Chiba, Kenzo; Sato, Yuki; Sawanishi, Hiroyuki Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 10 p. 1915 - 1924

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Citation Number: 32

Abstract

To elucidate the N-terminal structure–activity relationships of polymyxin B peptides, seven polymyxin B component peptides, the structures of which having been elucidated, and seven N-terminal fatty acid and/or amino acid deletion analogs were synthesized, and ...

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