DNA Repair 2015-06-01

SWI/SNF recruitment to a DNA double-strand break by the NuA4 and Gcn5 histone acetyltransferases.

Gwendolyn Bennett, Craig L Peterson

Index: DNA Repair (Amst.) 30 , 38-45, (2015)

Full Text: HTML

Abstract

The DNA damage response to double-strand breaks (DSBs) is critical for cellular viability. Recent work has shown that a host of chromatin regulators are recruited to a DSB, and that they are important for the DNA damage response. However, the functional relationships between different chromatin regulators at DSBs remain unclear. Here we describe a conserved functional interaction among the chromatin remodeling enzyme, SWI/SNF, the NuA4 and Gcn5 histone acetyltransferases, and phosphorylation of histone H2A.X (γH2AX). Specifically, we find that the NuA4 and Gcn5 enzymes are both required for the robust recruitment of SWI/SNF to a DSB, which in turn promotes the phosphorylation of H2A.X. Copyright © 2015 Elsevier B.V. All rights reserved.

Related Compounds

  • Ethanol
  • 1-Naphthaleneaceti...
  • Potassium 1-naphth...
  • Nocodazole

Related Articles:

Genetic and pharmacologic inhibition of eIF4E reduces breast cancer cell migration, invasion, and metastasis.

2015-03-15

[Cancer Res. 75(6) , 1102-12, (2015)]

Aptamer-based polyvalent ligands for regulated cell attachment on the hydrogel surface.

2015-04-13

[Biomacromolecules 16(4) , 1382-9, (2015)]

25-O-acetyl-23,24-dihydro-cucurbitacin F induces cell cycle G2/M arrest and apoptosis in human soft tissue sarcoma cells.

2015-04-22

[J. Ethnopharmacol. 164 , 265-72, (2015)]

Improved ethanol tolerance and ethanol production from glycerol in a streptomycin-resistant Klebsiella variicola mutant obtained by ribosome engineering.

2015-01-01

[Bioresour. Technol. 176 , 156-62, (2014)]

Polymerization of affinity ligands on a surface for enhanced ligand display and cell binding.

2014-12-08

[Biomacromolecules 15(12) , 4561-9, (2014)]

More Articles...