Antimicrobial Agents and Chemotherapy 2015-09-01

Development of a novel formulation with hypericin to treat cutaneous leishmaniasis based on photodynamic therapy in in vitro and in vivo studies.

Andrés Montoya, Alejandro Daza, Diana Muñoz, Karina Ríos, Viviana Taylor, David Cedeño, Iván D Vélez, Fernando Echeverri, Sara M Robledo

Index: Antimicrob. Agents Chemother. 59 , 5804-13, (2015)

Full Text: HTML

Abstract

An evaluation of the leishmanicidal activity in vitro and in vivo of hypericin, an expanded-spectrum photosensitizer found in Hypericum perforatum, is presented. Hypericin was evaluated against intracellular amastigotes in vitro of Leishmania (Viannia) panamensis. A topical formulation containing 0.5% hypericin was developed and assayed in vivo in a hamster model of cutaneous leishmaniasis. Results demonstrate that hypericin induces a significant antiamastigote effect in vitro against L. panamensis by decreasing the number of parasites inside infected cells. The topical formulation of 0.5% hypericin allows healing of L. panamensis-induced lesions upon a topical application of 40 mg/day plus visible-light irradiation (5 J/cm(2), 15 min), twice a week for 3 weeks. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Related Compounds

  • Ethanol
  • Hypericin
  • meglumine

Related Articles:

Genetic and pharmacologic inhibition of eIF4E reduces breast cancer cell migration, invasion, and metastasis.

2015-03-15

[Cancer Res. 75(6) , 1102-12, (2015)]

Aptamer-based polyvalent ligands for regulated cell attachment on the hydrogel surface.

2015-04-13

[Biomacromolecules 16(4) , 1382-9, (2015)]

25-O-acetyl-23,24-dihydro-cucurbitacin F induces cell cycle G2/M arrest and apoptosis in human soft tissue sarcoma cells.

2015-04-22

[J. Ethnopharmacol. 164 , 265-72, (2015)]

Improved ethanol tolerance and ethanol production from glycerol in a streptomycin-resistant Klebsiella variicola mutant obtained by ribosome engineering.

2015-01-01

[Bioresour. Technol. 176 , 156-62, (2014)]

Polymerization of affinity ligands on a surface for enhanced ligand display and cell binding.

2014-12-08

[Biomacromolecules 15(12) , 4561-9, (2014)]

More Articles...