Contact Dermatitis 1989-01-01

The irritancy and allergenicity of 2-n-octyl-4-isothiazolin-3-one (Skane M-8), with recommendations for patch test concentration.

E A Emmett, S K Ng, M A Levy, J N Moss, I J Morici

Index: Contact Dermatitis 20(1) , 21-6, (1989)

Full Text: HTML

Abstract

Preparations of 2-n-octyl-4-isothiazolin-3-one (Skane M-8) at 1000 p.p.m. a.i. and 500 p.p.m. a.i. in pet. induced allergy in a cumulative insult human patch test. Challenge patch testing using 250 p.p.m. a.i. Skane M-8 elicited allergy in 6 out of 6 sensitized individuals. Sensitized individuals did not cross react with Kathon biocide, (Kathon CG), a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one. All pretrolatum preparations to which Tween 85 was added at 2.5% produced mild irritation in cumulative insult patch tests, but no irritation was observed with Tween 85 at 0.625%. We conclude that Skane M-8, 250 p.p.m. a.i. with Tween 85 0.625% in petrolatum is appropriate for patch testing for Skane M-8 allergy.

Related Compounds

  • 2-Octyl-2H-isothi...

Related Articles:

Contact dermatitis from 2-n-octyl-4-isothiazolin-3-one in a PhD student.

2004-01-01

[Contact Dermatitis 50(1) , 47-8, (2004)]

Allergic contact dermatitis from 2-n-octyl-4-isothiazolin-3-one, a paint mildewcide.

1983-11-01

[Contact Dermatitis 9(6) , 507-9, (1983)]

[Allergic contact eczema caused by isothiazolin-3-one derivatives].

1984-01-01

[Derm. Beruf Umwelt. 32(6) , 208-11, (1984)]

A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors.

2009-07-01

[Br. J. Pharmacol. 157(6) , 974-83, (2009)]

Benzisothiazolinone as a useful template for the design of new monoacylglycerol lipase inhibitors: investigation of the target residues and comparison with octhilinone.

2011-12-15

[Bioorg. Med. Chem. Lett. 21(24) , 7321-4, (2011)]

More Articles...