Biomaterials, Artificial Cells and Immobilization Biotechnology 1992-01-01

Diaspirin cross-linked hemoglobin solution as a resuscitative fluid following severe hemorrhage in the rat.

D Malcolm, D Kissinger, M Garrioch

Index: Biomater. Artif. Cells Immobilization Biotechnol. 20(2-4) , 495-7, (1992)

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Abstract

The effect of diaspirin cross-linked hemoglobin (DCLHb) on mean arterial pressure (MAP) and heart rate (HR) was compared to Ringer's lactate (RL) and shed blood in a 70% lethal model of hemorrhage (35 cc/kg blood loss) in conscious rats. All animals resuscitated with DCLHb regardless of dose (17.5 and 35 cc/kg) and concentration (7% and 10% solution) exhibited complete restoration of MAP and HR which was maintained for at least 5 hrs. Hemodynamic responses in DCLHb-treated animals were not significantly different from 35 cc/kg blood-treated animals. In RL (105 cc/kg) treated animals the MAP was restored to 60-70% of baseline. 24 hr survival in animals resuscitated with fluids ranged between 88-100% and was not significantly different between treatment groups.

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