Aza-analogue dibenzepinone scaffolds as p38 mitogen-activated protein kinase inhibitors: design, synthesis, and biological data of inhibitors with improved …

SC Karcher, SA Laufer

Index: Karcher, Solveigh C.; Laufer, Stefan A. Journal of Medicinal Chemistry, 2009 , vol. 52, # 6 p. 1778 - 1782

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Citation Number: 18

Abstract

We recently described a promising novel class of p38 mitogen activated protein (MAP) kinase inhibitors with dibenzepinone-scaffolds. To optimize their physicochemical properties, characterized by calculated log P values and measured lipophilicity (chromatographic hydrophobicity index= CHI), we synthesized aza-analogue dibenzepinones. Here, we present the synthesis and biological data of compounds with ...