Bioorganic & Medicinal Chemistry 2008-01-01

Synthesis and cytotoxic activities of usnic acid derivatives

Marc-Antoine Bazin, Anne-Cécile Le Lamer, Jean-Guy Delcros, Isabelle Rouaud, Philippe Uriac, Joël Boustie, Jean-Charles Corbel, Sophie Tomasi, Marc-Antoine Bazin, Anne-Cécile Le Lamer, Jean-Guy Delcros, Isabelle Rouaud, Philippe Uriac, Joël Boustie, Jean-Charles Corbel, Sophie Tomasi

Index: Bioorg. Med. Chem. 16 , 6860-6, (2008)

Full Text: HTML

Abstract

Cytotoxic evaluation of enamines derived from (+)-usnic acid led us to the selection of the diaminooctane derivative as active towards cancer cell lines (2.7 < IC 50 < 14.1 μM). Apoptotic effect was also observed.

Related Compounds

  • spermidine
  • putrescine
  • Spermine
  • 1,8-Diaminooctane

Related Articles:

TYLCV-Is movement in planta does not require V2 protein.

2015-03-01

[Virology 477 , 56-60, (2015)]

Hypoxia reduces MAX expression in endothelial cells by unproductive splicing.

2014-12-20

[FEBS Lett. 588(24) , 4784-90, (2014)]

H4 histamine receptors inhibit steroidogenesis and proliferation in Leydig cells.

2014-12-01

[J. Endocrinol. 223(3) , 241-53, (2014)]

Long-distance retinoid signaling in the zebra finch brain.

2014-01-01

[PLoS ONE 9(11) , e111722, (2014)]

Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress.

2015-01-01

[Toxicol. Appl. Pharmacol. 282(1) , 77-89, (2015)]

More Articles...