1-(1, 2, 5-Thiadiazol-4-yl)-4-azatricyclo [2.2. 1.02, 6] heptanes as New Potent Muscarinic M1 Agonists: Structure-Activity Relationship for 3-Aryl-2-propyn-1-yloxy and 3 …

L Jeppesen, PH Olesen, L Hansen…

Index: Journal of Medicinal Chemistry, , vol. 42, # 11 p. 1999 - 2006

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Citation Number: 17

Abstract

... Journal of Medicinal Chemistry. ... Chemistry. The syntheses of the azatricyclic thiadiazoles 8a−h and 9a−h began with the known 1-cyano-4-azatricyclo[2.2. 1.0 2,6 ]heptane 14 (Scheme 2), which is obtained by reaction ...

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