Molecules 2012-01-01

Synthesis of 9,9'-[1,2-ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6H-purin-6-one, an impurity of acyclovir.

Rosa M Suárez, Maria Paz Matía, José Luis Novella, Andres Molina, Antonio Cosme, Juan José Vaquero, Julio Alvarez-Builla

Index: Molecules 17(8) , 8735-41, (2012)

Full Text: HTML

Abstract

The synthesis of 9,9'-[1,2-ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6H-purin-6-one, a minor impurity of acyclovir, is described. Starting with commercial N-(9-acetyl-6-oxo-1H-purin-2-yl)acetamide, the process uses an acid catalysed phase transfer catalysis (PTC) process to produce the selective alkylation at the 9 position of the guanine ring.

Related Compounds

  • N,N,N-Tributyl-1...
  • Paraformaldehyde
  • Tetrabutylammonium...
  • Tetrabutylammonium...
  • 2-Aminopurine
  • Tetrabutylammonium...
  • Tetrabutylammonium...
  • Tetrabutylammonium...
  • Tetrabutylammonium...
  • Tetrabutylammonium...

Related Articles:

High-turnover hypoiodite catalysis for asymmetric synthesis of tocopherols.

2014-07-18

[Science 345(6194) , 291-4, (2014)]

Tandem cyclization of α-cyano α-alkynyl aryl ketones induced by tert-butyl hydroperoxide and tetrabutylammonium iodide.

2012-12-07

[Org. Lett. 14(23) , 6024-7, (2012)]

RNA editing in eag potassium channels: biophysical consequences of editing a conserved S6 residue.

2012-01-01

[Channels (Austin.) 6(6) , 443-52, (2012)]

Quantitative imaging of ion transport through single nanopores by high-resolution scanning electrochemical microscopy.

2012-06-20

[J. Am. Chem. Soc. 134(24) , 9856-9, (2012)]

Photoinduced ligand exchange and DNA binding of cis-[Ru(phpy)(phen)(CH3CN)2]+ with long wavelength visible light.

2013-04-01

[J. Inorg. Biochem. 121 , 77-87, (2013)]

More Articles...