An improved approach to N-substituted maleimides and phthalimides by microwave-promoted Mitsunobu reaction

CD Mayer, M Kehrel, F Bracher

Index: Mayer, Christoph D.; Kehrel, Marcus; Bracher, Franz Organic Preparations and Procedures International, 2008 , vol. 40, # 6 p. 574 - 574

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Citation Number: 7

Abstract

Maleimide derivatives are of high interest as substrates in biological applications. Due to its Michael-accepting ability the maleimido group is able to react with nucleophilic groups, eg thiol groups in biomolecules. I Therefore substrates containing terminal maleimido functionality can undergo covalent coupling to cysteine residues of enzymes or other proteins? Bifunctional derivatives with a maleimido group attached to one end and a ...