Sequential Metal??Catalyzed N??Heteroarylation and C–C Cross??Coupling Reactions: An Expedient Route to Tris (hetero) aryl Systems

JS Siddle, AS Batsanov…

Index: Siddle, Jamie S.; Batsanov, Andrei S.; Bryce, Martin R. European Journal of Organic Chemistry, 2008 , # 16 p. 2746 - 2750

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Citation Number: 16

Abstract

Abstract This paper describes copper-catalyzed N–C heteroarylation of benzimidazole, 1- methylbenzimidazolone, imidazole and pyrrole. The products of these reactions then undergo palladium-catalyzed C–C cross-couplings with aryl or heteroarylboronic acids under Suzuki–Miyaura conditions to provide a rapid entry, from readily-available reagents, into tris (hetero) aryl scaffolds comprising two or three N-heterocyclic rings. The sequential ...