Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 2012-01-01

[Dynamics of proinflammatory cytokines during biologic therapy of inflammatory bowel disease].

V E Sagynbaeva, L B Lazebnik, O V Kniazev, L I Efremov

Index: Eksp. Klin. Gastroenterol. (3) , 47-58, (2012)

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Abstract

Chronic inflammation in IBD is accompanied by an imbalance in the production of Tx1 and Tx2 cytokines. Imbalance of cytokine profile is important pathogenetic importance in chronic inflammatory process, since the formation of defective immune response to pathogenic agent promotes recurrence of the disease. Analysis of the dynamics of proinflammatory cytokines allows both the activity of inflammatory process and effectiveness. Increased levels of proinflammatory cytokines: TNF-alpha, IFN-gamma, IL-2, IL-5, IL-8, IL-12, IL-15 in serum of patients with IBD, indicate their possible involvement in the mechanisms of development of CD and UC. Increasing content of these cytokines is accompanied by increased activity of disease, which can be used in diagnose IBD activity.

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