Synthesis and pharmacological evaluation of pyrazolopyrimidopyrimidine derivatives: anti-inflammatory agents with gastroprotective effect in rats

…, F Allouche, M Deghrigue, A Agrebi, A Bouraoui…

Index: Karoui, Amine; Allouche, Fatma; Deghrigue, Monia; Agrebi, Asma; Bouraoui, Abderrahman; Chabchoub, Fakher Medicinal Chemistry Research, 2014 , vol. 23, # 3 p. 1591 - 1598

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Citation Number: 7

Abstract

Abstract We report the synthesis of new anti-inflammatory 1, 7-dihydropyrazolo [3′, 4′: 4, 5] pyrimido [1, 6-a] pyrimidine 5 from aminocyanopyrazole. All compounds were characterized by physical, chemical and spectral studies. Preliminary pharmacological evaluation of the resulting products showed that compounds 5a, b, f (50–100 mg/kg, ip) are active anti-inflammatory agents in carrageenan-induced rat paw oedema assay, and their ...