Tetrahedron letters

Application of yeast-catalyzed reductions to synthesis of (2R, 3S)-phenylisoserine

J Kearns, MM Kayser

Index: Kearns, Jeff; Kayser, Margaret Tetrahedron Letters, 1994 , vol. 35, # 18 p. 2845 - 2848

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Citation Number: 51

Abstract

Abstract A simple synthesis of (2R, 3S)-phenylisoserine, a precursor of the C-13 side chain of Taxol®(paclitaxel), utilising yeast-catalyzed reduction to generate a second chiral centre is reported. This short enantioselective series of transformations can be readily adapted to large scale production of a variety of N-substituted paclitaxel analogues.