Toxicology Letters 1994-06-01

Toxicity of monocyclic and polycyclic nitroaromatic compounds in a panel of mammalian test cell lines.

M M Perchermeier, F Kiefer, F J Wiebel

Index: Toxicol. Lett. 72(1-3) , 53-7, (1994)

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Abstract

The cytotoxicity of polycyclic and monocyclic nitroarenes was tested in cell lines V79/NH, H4IIEC3/G-, 5L and BWI-J, which are distinguished by their specific expression of xenobiotic metabolizing enzymes. The results show that polycyclic nitroarenes differentially affect the test cell lines suggesting that some compounds, such as 1,3-dinitropyrene, are activated by cytochrome P4501A1, others, such as 1,6-dinitropyrene, by reductase(s) and acetyltransferase. No such cell specific responses were seen for 13 monocyclic nitroarenes tested. This group of chemicals apparently is activated by an enzyme(s) other than the polycyclic nitroarenes tested.

Related Compounds

  • 1,3-Dinitropyrene

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