AAPS PharmSciTech 2009-01-01

Improving tenoxicam solubility and bioavailability by cosolvent system.

Ming-Kung Yeh, Li-Chien Chang, Andy Hong-Jey Chiou

Index: AAPS PharmSciTech 10(1) , 166-71, (2009)

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Abstract

The formulation study of tenoxicam, a poorly water-soluble drug, was developed by use of a ternary cosolvent system and has significantly enhanced the solubility. Additionally, the relative bioavailability of testing formulation was also evaluated by New Zealand rabbit with a single i.m. injection. The three-phase diagram for dimethylsulfoxide (DMSO)/propylene glycol/water, DMSO/ethanol/water, and DMSO/polyethoxylated castor oil/ethanol system was developed. The volume ratio of 5:4:1 in the DMSO/polyethoxylated castor oil/ethanol system resulted in a more suitable vehicle than other systems, with a high solubility (20.73 mg/ml) and low viscosity (10.0 Cp). A pharmacokinetic study of bioequivalence (F (rel) = 0.89) was also obtained. The present study not only provides a novel strategy improving tenoxicam solubility but also helps further scientific knowledge for the development of parenteral formulations.

Related Compounds

  • Ethoxylated hydrog...
  • Cremophor EL

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