Chemical Communications 2013-01-21

Three-component access to pyrroles promoted by the CAN-silver nitrate system under high-speed vibration milling conditions: a generalization of the Hantzsch pyrrole synthesis.

Verónica Estévez, Mercedes Villacampa, J Carlos Menéndez

Index: Chem. Commun. (Camb.) 49(6) , 591-3, (2013)

Full Text: HTML

Abstract

A sequential multicomponent process involving the high-speed vibration milling of ketones with N-iodosuccinimide and p-toluenesulfonic acid, followed by addition of a mixture of primary amines, β-dicarbonyl compounds, cerium(IV) ammonium nitrate and silver nitrate afforded polysubstituted, functionalized pyrroles. This one-pot, solid-state process can be considered as the coupling of an α-iodoketone preparation with a general version of the classical Hantzsch pyrrole synthesis.

Related Compounds

  • Sodium p-toluenesu...
  • Silver nitrate
  • Cesium
  • p-Toluenesulfonic...
  • Silver(1+) 4-methy...
  • ZINC(II) P-TO...
  • N-iodosuccinimide

Related Articles:

Supported p-toluenesulfonic acid as a highly robust and eco-friendly isocyanide scavenger.

2011-01-10

[ACS Comb. Sci. 13(1) , 89-95, (2011)]

The transporter-opsin-G protein-coupled receptor (TOG) superfamily.

2013-11-01

[FEBS J. 280(22) , 5780-800, (2013)]

Coumarin–trioxane hybrids: Synthesis and evaluation as a new class of antimalarial scaffolds

2012-06-15

[Bioorg. Med. Chem. Lett. 22(12) , 3926-30, (2012)]

Catalytic asymmetric construction of spiro(γ-butyrolactam-γ-butyrolactone) moieties through sequential reactions of cyclic imino esters with Morita-Baylis-Hillman bromides.

2012-10-01

[Chemistry 18(40) , 12614-8, (2012)]

Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria.

2012-09-15

[Int. J. Pharm. 434(1-2) , 148-54, (2012)]

More Articles...