Synlett

Copper-catalyzed amidation of aryl iodides using KF/Al2O3: An improved protocol

R Hosseinzadeh, M Tajbakhsh, M Mohadjerani…

Index: Hosseinzadeh, Rahman; Tajbakhsh, Mahmood; Mohadjerani, Maryam; Mehdinejad, Hamidreza Synlett, 2004 , # 9 p. 1517 - 1520

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Citation Number: 38

Abstract

Abstract A mild method for the copper-catalyzed amidation of aryl iodides is reported. This simple CN bond forming procedure shows that the combination of air stable CuI and 1, 10- phenanthroline in the presence of KF/Al 2 O 3 comprises an extremely efficient and general catalyst system for the N-amidation of aryl iodides. Different functionalized aryl iodides were efficiently coupled with amides using this method.

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