One-Pot Preparation of 2, 5-Dichloro-4′-phenyloxybenzophenone

MC Davis, TJ Groshens

Index: Davis, Matthew C.; Groshens, Thomas J. Synthetic Communications, 2011 , vol. 41, # 2 p. 255 - 261

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Abstract

Friedel–Crafts-type acylation of phenyl ether with 2, 5-dichlorobenzoic acid could be accomplished in a single step using trifluoroacetic anhydride and phosphoric acid. The method gave a greater yield (78%) than the conventional two-step process (71%) of acid chloride generation followed by aluminum trichloride–mediated acylation.