Journal of Analytical Toxicology 2015-03-01

Analysis of psilocin, bufotenine and LSD in hair.

Rafaela Martin, Jennifer Schürenkamp, Angela Gasse, Heidi Pfeiffer, Helga Köhler

Index: J. Anal. Toxicol. 39(2) , 126-9, (2015)

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Abstract

A method for the simultaneous extraction of the hallucinogens psilocin, bufotenine, lysergic acid diethylamide (LSD) as well as iso-LSD, nor-LSD and O-H-LSD from hair with hydrochloride acid and methanol is presented. Clean-up of the hair extracts is performed with solid phase extraction using a mixed-mode cation exchanger. Extracts are measured with liquid chromatography coupled with electrospray tandem mass spectrometry. The method was successfully validated according to the guidelines of the 'Society of Toxicological and Forensic Chemistry' (GTFCh). To obtain reference material hair was soaked in a solution of the analytes in dimethyl sulfoxide/methanol to allow incorporation into the hair. These fortified hair samples were used for method development and can be employed as quality controls. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Related Compounds

  • Acetonitrile
  • Methanol
  • Psilocin
  • lsd

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