Peroxisome proliferator-activated receptor-γ mediates the anti-inflammatory effect of 3-hydroxy-4-pyridinecarboxylic acid derivatives: Synthesis and biological …

…, A Dean, V Di Marco, P Surajit, I Castagliuolo…

Index: Brun, Paola; Dean, Annalisa; Di Marco, Valerio; Surajit, Pathak; Castagliuolo, Ignazio; Carta, Davide; Ferlin, Maria Grazia European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 486 - 497

Full Text: HTML

Citation Number: 14

Abstract

Seven 3-hydroxy-4-pyridinecarboxylic acid derivatives (HPs), aza-analogues of salicylic acid and structurally close to other potent inflammatory pyridine compounds such as aminopyridinylmethanols and aminopyridinamines, were synthesized, and their anti- inflammatory activity was evaluated. The synthesis was performed by adopting a general procedure involving an intramolecular Diels–Alder cycloaddition of oxazoles with acrylic ...

Related Articles:

Regioselectivity of pyrrole synthesis from diethyl aminomalonate and 1, 3-diketones: further observations

[Paine, John B.; Brough, Jonathan R.; Buller, Kathy K.; Erikson, Erika E. Journal of Organic Chemistry, 1987 , vol. 52, # 18 p. 3986 - 3993]

The synthesis and application of novel nitrating and nitrosating agents

[Hakimelahi, Gholam H.; Sharghi, Hashem; Zarrinmayeh, Hamide; Khalafi-Nezhad, Ali Helvetica Chimica Acta, 1984 , vol. 67, p. 906 - 915]

Amination of ester enolates with O-(2, 4-dinitrophenyl) hydroxylamine

[Journal of Organic Chemistry, , vol. 44, p. 4836 - 4841]

Organic compounds of fluorine. XI. The synthesis of δ, δ-difluoronorleucine

[Collection of Czechoslovak Chemical Communications, , vol. 32, p. 453 - 457]

More Articles...